158 papers
This study demonstrates that analyzing the relative fraction of cardiac troponin bound to circulating extracellular vesicles versus free plasma serves as a novel, specific biomarker capable of distinguishing between ischemic myocardial infarction and non-ischemic injury caused by tachyarrhythmia.
While blood transfusions generally showed an association with reduced hospital-free days in patients with congestive heart failure and hemoglobin levels of 6.5–7.4 g/dL, causal forest analysis revealed heterogeneous effects suggesting potential benefits for patients transfused on the first day of hospitalization or those with low serum bicarbonate concentrations.
This propensity score-matched analysis of CKD patients undergoing PCI reveals that an elevated calcium-phosphate product is an independent predictor of significantly worse long-term outcomes, including higher rates of all-cause mortality, heart failure exacerbations, in-stent restenosis, and recurrent myocardial infarction.
This single-center retrospective study of 1,101 patients undergoing transfemoral TAVR found that the use of cerebral embolic protection devices was significantly associated with a reduced incidence of early periprocedural ischemic stroke, although no significant differences were observed for other neurological outcomes or short-term mortality.
This study demonstrates that peripheral blood mononuclear cell transcriptomic profiles are associated with long-term changes in carotid intima-media thickness, revealing that while cross-sectional immune signatures reflect immediate immune activation, longitudinal signatures linked to vascular remodeling are enriched for metabolic and redox pathways.
This retrospective cohort study utilizing TriNetX data reveals that adolescents and young adults who vape face a significantly increased risk of heart rhythm abnormalities, with odds nearly double those of non-vapers.
This integrated safety analysis of nearly 700 patient-years across four clinical trials demonstrates that aficamten is well tolerated with a favorable safety profile in patients with obstructive hypertrophic cardiomyopathy, showing low rates of clinically relevant systolic dysfunction and atrial fibrillation comparable to placebo or metoprolol.
This case report demonstrates that an externally validated artificial intelligence model applied to echocardiography can detect cardiac amyloidosis approximately 218 days before clinical diagnosis, offering a promising tool for earlier patient identification and timely treatment.
This study demonstrates that NOX4 plays a pathogenic role in abdominal aortic aneurysm (AAA) by driving extracellular matrix remodeling and facilitating the transdifferentiation of lymphatic endothelial cells into myofibroblasts, thereby linking lymphangiogenesis to fibrotic progression.
This multi-cohort study utilizing multi-state models demonstrates that lower socioeconomic status significantly accelerates the progression of cardiometabolic multimorbidity from initial disease onset to mortality and shortens survival time across diverse populations, highlighting the critical need to integrate socioeconomic factors into clinical management strategies.
The ClinGen Dilated Cardiomyopathy Gene Curation Expert Panel's 2024-2025 reassessment significantly expanded the known genetic architecture of DCM by classifying 35 gene-disease relationships as high evidence, including 11 newly identified autosomal recessive genes, thereby providing an updated, evidence-based framework to guide clinical genetic testing and care.
This multi-cohort study demonstrates that longitudinal transitions and cumulative burdens of handgrip strength are stronger predictors of incident cardiovascular disease risk than single baseline measurements, particularly in East Asian populations, highlighting the clinical value of monitoring dynamic changes in muscle strength for CVD prevention.
This study demonstrates that a physiology-informed digital twin-AI framework can predict individual hemodynamic and energetic responses to accelerated atrial pacing in HFpEF patients, identifying cardiac efficiency improvement and systolic blood pressure reduction as key mechanistic and clinical indicators of treatment benefit.
This study identifies a 94-metabolite signature associated with body mass index that predicts incident coronary heart disease and cardiovascular risk, demonstrating its potential as a biomarker that responds significantly to metabolic and bariatric surgery.
This multicenter study of 119 patients demonstrates that monitoring real-time electrical parameters, specifically initial current of injury increases and impedance thresholds exceeding 230 Ω, during Aveir VR leadless pacemaker implantation effectively guides site localization and predicts short-term device stability and pacing performance.
In a single-center study of 727 TAVR patients, overall neighborhood-level social deprivation was not independently associated with one-year mortality, although a specific marker of social fragmentation (single-parent household density) was identified as a significant predictor of increased mortality risk.
This study analyzes the "Autonomic Aging" dataset of 1,121 healthy adults to demonstrate that age, sex, and BMI significantly influence resting ECG intervals and their variabilities, identifying age 50 as a critical transition point for cardiac aging and revealing that the active interval's duration and variability are more indicative of heart health than the RR interval.
This prospective study validates the use of non-invasive left ventricular pressure-strain loop (LV-PSL) indices as a reproducible and physiologically sensitive surrogate for assessing ventriculo-arterial coupling, demonstrating that these metrics correctly distinguish between contractility-dominant and afterload-dominant hemodynamic perturbations in healthy adults.
This study developed and validated condition-specific machine learning models using administrative data from a large, predominantly Black statewide cohort to achieve moderate-to-high discrimination in predicting 30-day cardiovascular readmissions, identifying key clinical indices and insurance status as dominant predictors to support equity-informed interventions in safety-net healthcare systems.
This study demonstrates that heart failure with preserved and reduced ejection fraction represent two distinct mechanistic phenotypes of diastolic dysfunction, characterized by increased damping in the former and reduced damping in the latter, despite similar conventional echocardiographic measures.